Skip Navigation

COVID-19 Updates

Review our resources for guidelines about COVID-19.

Find a Doctor

Find a Researcher

Christopher J Earley, M.B.B.Ch., Ph.D.

Headshot of Christopher J Earley
  • Professor of Neurology
Male

Expertise

Circadian Rhythm Disorders, Insomnia, Narcolepsy，神经学，不宁腿综合症，睡眠呼吸暂停，睡眠障碍，睡眠医学 ...read more

Research Interests

Restless Legs Syndrome; Sleep

Play Video:

不宁腿综合征药物性症状增强的生物学基础及治疗

Request an Appointment

Insurance Information

Existing Patients

Request your next appointment through MyChart

Main Phone

410-550-0571

Outside of Maryland & Washington D.C.

410-464-6641
Request Appointment

International Patients

+1-410-502-7683
Request Appointment

Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-0571
5501 Hopkins Bayview Circle
Asthma and Allergy Center 1B-82
Baltimore, MD 21224 map
Phone: 410-550-0571 | Fax: 410-367-2710

Background

Dr. Christopher Earley的研究和临床兴趣致力于睡眠医学，对不宁腿综合征特别感兴趣. 他目前的研究重点是了解不宁腿综合征的病理生理学，并进一步阐明该综合征的各种治疗价值.

Dr. Earley获得了戈尔韦大学学院的医学学位和药理学博士学位, Ireland. 他在贝勒医学院完成了内科的住院实习，然后去了夏洛茨维尔的弗吉尼亚大学完成了神经病学的住院实习. 之后在美国国立卫生研究院神经生物学部门工作了一年. Earley joined the faculty at Johns Hopkins in 1991.

2008 Professor, Department of Neurology, Johns Hopkins
1994- Associate Director, Sleep Disorders Center, JHBMC
Education and Training:
1973 - B.S. (General), Villanova University
1974 - B.A. (Psychology), Arizona State University
1978 - Ph.D. (Pharmacology), National University of Ireland
1983 - M.B., B.Ch. ( Medicine), National University of Ireland
1983-1984 Internship, University Hospital, Galway, Ireland
1984-1987 贝勒医学院内科住院医师，休斯顿，德克萨斯州
1987-1990 Resident in Neurology, University of Virginia, Charlottesville, VA
1990-1991 Senior Staff Fellow, Neurobiology Unit, NIH/NIA
Professional Experience:
1991- Full-time Staff Neurologist, Johns Hopkins
1992-1999 Assistant Professor, Department of Neurology, Johns Hopkins
1993-2001 Director, Acute Stroke Service,
1994- Associate Director, Sleep Disorders Center
1994-1999 Co-Director, Neurosciences Critical Care Unit
1996-2000 Director, Neurovascular Ultrasound Lab
1999-2008 Associate Professor, Department of Neurology, Johns Hopkins

...read more

Titles

  • Professor of Neurology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MBBCh PhD; University College Hospital (1983)

Residencies

  • Internal Medicine; Baylor College of Medicine (1987)
  • Neurology; University of Virginia School of Medicine (1990)

Fellowships

  • National Institutes of Health (1991)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (1987)
  • American Board of Psychiatry And Neurology (Neurology) (1993)

Research & Publications

Clinical Trial Keywords

Restless; Daytime Drowsiness; Restless Legs Syndrome

Selected Publications

1. Silver N, Allen RP, Senerth J, Earley CJ. A 10-year, 多巴胺激动剂和美沙酮治疗不宁腿综合征的纵向评价. Sleep Medicine. 2011 12(5):440-4.


2. 温克尔曼J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C，等. 全基因组关联研究发现2p14和16q12上新的不宁腿综合征易感位点.1. PLoS Genet. 2011;7(7):e1002171.


3. Edwards RR, Quartana PJ, Allen RP, Greenbaum S, Earley CJ, Smith MT. 不宁腿综合征治疗和未治疗患者疼痛反应的改变:与睡眠中断的关系. Sleep Medicine. 2011;12(6):603-9.


4. Earley CJ, Kuwabara H, Wong DF, Gamaldo C, Salas R, Brasic J, et al. 不宁腿综合征患者纹状体中多巴胺转运体减少. Sleep. 2011;34(3):341-7. PMCID: 3041710.


5. Connor JR, Ponnuru P, Wang X-S, Patton SM, Allen RP, Earley CJ. Profile of altered brain iron acquisition in restless legs syndrome. Brain. 2011;134(4):959-68. PMCID: 3069701.


6. Connor JR, Ponnuru P, Lee B-Y, Podskalny GD, Alam S, Allen RP, et al. 尸检和影像学分析显示不宁腿综合征的中枢神经系统髓鞘形成减少. Sleep Medicine. 2011;12(6):614-19.


7. Quiroz C, Pearson V, Gulyani S, Allen R, Earley C, Ferre S. 缺铁大鼠纹状体腺苷A(2A)受体上调:对运动和皮质纹状体神经传递的影响. Exp Neurol. 2010;224(1):292-8. PMCID: 2885550.


8. Pantaleo NP, Hening WA, Allen RP, Earley CJ. 妊娠是家族性RLS患病率性别差异的主要原因. Sleep Med. 2010;11:310-3. PMCID: 2830334.


9. Earley CJ, Silber MH. 不宁腿综合征:了解其后果和需要更好的治疗. Sleep Medicine. 2010;11(9):807-15.


10. Xiong L, Catoire H, Dion P, Gaspar C, Lafreniere RG, Girard SL, et al. 与不宁腿综合征相关的MEIS1内含子风险单倍型影响其mRNA和蛋白表达水平. Hum Mol Genet. 2009;18(6):1065-74. PMCID: 2722232.


11. Unger EL, Earley CJ, Beard JL. Diurnal cycle influences peripheral and brain iron levels in mice. J Appl Physiol. 2009;106:187-93. PMCID: 2636939.


12. Snyder AM, Wang X, Patton SM, Arosio P, Levi S, Earley CJ, et al. 不宁腿综合征黑质线粒体铁蛋白的研究. J Neuropathol Exp Neurol. 2009;68(11):1193-9. PMCID: 3024883.


13. Salas RE, Gamaldo CE, Allen RP, Earley CJ. 静源性夜间运动障碍:一种不宁腿综合征(RLS)变体或一种新的综合征? Sleep Med. 2009;10:396-7.


14. Hening WA, Allen RP, Washburn M, Lesage SR, Earley CJ. 不宁腿综合征的四种诊断标准不能排除混杂条件(“模仿”)。. Sleep Medicine. 2009;10(9):976-81. PMCID: 2766267.


15. Gulyani S, Earley CJ, Camandola S, Maudsley S, Ferr S, Mughal MR，等. 铁浓度降低可增加小鼠纹状体和培养的人神经母细胞瘤细胞中腺苷A2A受体的水平. Experimental Neurology. 2009;215(2):236-42. PMCID: 2784599.


16. Gamaldo C, Benbrook AR, Allen RP, Oguntimein O, Earley CJ. 评估不宁腿综合征(RLS)患者与睡眠受限对照组的日间警觉性. Sleep Medicine. 2009;10(1):134-8. PMCID: 2650846.


17. Earley CJ, Horska A, Mohamed MA, Barker PB, Beard JL, Allen RP. A randomized, double-blind, 静脉注射蔗糖铁治疗不宁腿综合征的安慰剂对照试验. Sleep Med. 2009;10(2):206-11. PMCID: 2703581.


18. Earley CJ, Allen RP, Connor JR, Ferrucci L, Troncoso J. RLS尸检脑组织A11系统多巴胺能神经元显示正常. Sleep Med. 2009;10(10):1155-7. PMCID: 2783651.


19. Earley CJ. The importance of oral iron therapy in restless legs syndrome. Sleep Medicine. 2009;10(9):945-6.


20. Connor JR, Wang XS, Allen RP, Beard JL, Wiesinger JA, Felt BT, et al. 不宁腿综合征中壳核和黑质多巴胺能谱的改变. Brain. 2009;132(Sep):2403-12. PMCID: 2732265.


21. Hening WA, Allen RP, Washburn M, Lesage S, Earley CJ. 不宁腿综合征的霍普金斯电话诊断访谈的验证. Sleep Medicine. 2008;9(3):283-9.


22. Gamaldo CE, Benbrook AR, Allen RP, Oguntimein O, Earley CJ. 对不宁腿综合征(RLS)相关认知缺陷的进一步评估. Sleep Medicine. 2008;9(5):500-5. PMCID: 2532669.


23. Earley CJ, Ponnuru P, Wang X, Patton SM, Conner JR, Beard JL, et al. 不宁腿综合征患者淋巴细胞铁代谢的改变. Sleep. 2008;31(6):847-52. PMCID: 2442411.


24. Cho YW, Shin WC, Yun CH, Hong SB, Kim JH, Allen RP, et al. Epidemiology of restless legs syndrome in Korean adults. Sleep. 2008;31(2):219-23. PMCID: 2225579.


25. Gamaldo CE, Benbrook AR, Allen RP, Scott JA, Henning WA, Earley CJ. 与不宁腿综合征(RLS)诊断相关的儿童和成人因素. Sleep Medicine. 2007;8(7-8):716-22.


26. Pearson VE, Allen RP, Dean T, Gamaldo CE, Lesage SR, Earley CJ. Cognitive deficits associated with restless legs syndrome (RLS). Sleep Med. 2006;7(1):25-30.


27. Earley CJ, Hyland K, Allen RP. 不宁腿综合征患者脑脊液多巴胺能测量的昼夜变化. Sleep Med. 2006;7(3):263-8.


28. Earley CJ, Barker PB, Horska A, Allen RP. 核磁共振成像测定早发性和晚发性不宁腿综合征患者脑铁浓度. Sleep Med. 2006;7:458-61.


29. Earley CJ, Allen RP. Restless legs syndrome augmentation associated with tramadol. Sleep Med. 2006;7(7):592-3.


30. Earley CJ, Heckler D, Allen RP. 反复静脉剂量的铁提供了有效的补充治疗不宁腿综合征. Sleep Med. 2005;6(4):301-5.


31. Earley CJ, Connor JR, Beard JL, Clardy SL, Allen RP. 脑脊液中铁蛋白水平与不宁腿综合征:不同临床表型的影响. Sleep. 2005;28(9):1069-75.


32. Earley CJ, Heckler D, Allen RP. 葡聚糖铁静脉注射治疗不宁腿综合征. Sleep Med. 2004;5(3):231-5.


33. Earley CJ. Clinical practice. Restless legs syndrome. N Engl J Med. 2003;348(21):2103-9.


34. Allen RP, La Buda MC, Becker P, Earley CJ. Family history study of the restless legs syndrome. Sleep Med. 2002;3(Suppl):S3-7.


35. Earley CJ, Hyland K, Allen RP. 不宁腿综合征患者的脑脊液多巴胺、血清素和生物蝶呤代谢物. Mov Disord. 2001;16(1):144-9.


36. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56(2):263-5.


37. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP. 不宁腿综合征患者脑脊液铁蛋白和转铁蛋白浓度异常. Neurology. 2000;54(8):1698-700.


38. Earley CJ, Yaffee JB, Allen RP. 培高利特治疗不宁腿综合征的随机、双盲、安慰剂对照试验. Neurology. 1998;51(6):1599-602.


39. Allen RP, Earley CJ. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep. 1996;19(3):205-13.

Activities & Honors

Honors

  • 睡眠科学奖是为了表彰在睡眠科学研究方面的杰出成就, AAN, 2007
  • Elected, Fellow, Royal College of Physician, Ireland (FRCP(I)) in recognition of my work in Restless Legs Syndrome, 2007

Memberships

  • American Academy of Sleep Medicine, 1997
    Fellow
  • Medical Advisory Board of the Restless Legs Syndrome Foundation, 1995
    Member
  • 不宁腿综合症基金会科学顾问委员会，2007年
    Member
  • Sleep Research Society, 2003
    Member
  • Society of Neuroscience, 2003
    Member
  • World Association of Sleep Medicine, 2005
    Member

Patient Ratings & Comments

患者评分分数是通过Press Ganey对全国CG-CAHPS医疗实践患者体验调查中与医生相关问题的所有回答的平均值. 回答以1到5分进行衡量，5分是最高分. 我们还通过Press Ganey收集了CG-CAHPS医疗实践调查的评论，并将其完整地展示出来. Patients are de-identified for confidentiality and patient privacy.

Is this you? Edit Profile
back to top button